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KMID : 0366220090440030172
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Korean Journal of Hematology
2009 Volume.44 No. 3 p.172 ~ p.176
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A Case of Multicentric Castleman’s Disease Diagnosed with Lymph Node Biopsy and Bone Marrow Examination
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Park Sang-Hyuk
Park Chan-Jeoung
Huh Joo-Ryung
Jang Sung-Su
Chi Hyun-Sook
Suh Chul-Won
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Abstract
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Castleman’s disease (CD) is an uncommon lymphoproliferative disorder presenting with a variable spectrum of clinical manifestations. CD is classified into two subtypes, Localized CD and Multicentric CD, by clinical manifestation, and is divided into 2 histopathologic types: a hyaline-vascular type (HV) or a plasma-cell type (PC). Multicentric CD show PC type predominantly and show systemic symptoms, such as fever, night sweat, malaise, ascites, edema, and more than half show multiple lymphadenopathy and hepatosplenomegaly. We report a case of 67 year old man with multicentric CD presented with fever of unknown origin and diagnosed with lymph node biopsy and bone marrow examination with a brief review of the literature.
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KEYWORD
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Multicentric Castleman’s disease, Lymph node biopsy, Bone marrow examination
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